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Recent studies have suggested that the region 15q26 is critical for normal diaphragm development. Small case series have reported a favourable effect of steroid administration prior to birth in infants with CDH, but the potential benefits of improved lung function may not outweigh the risks to other vital organ development. After recent advances in the care of these patients, several centres are now reporting survival rates >80%. Davenport, C. Fetal surgery for CDH was conceived when postnatal mortality was very high and the aetiology was thought to be attributable solely to compression of the lung by abdominal contents. Tweet WidgetFacebook LikeGoogle Plus One . Diaphragmatic rupture CHERUBS . Search for related content Related Content Related articles in this journal Perioperative Management Load related web page information Share Email this article CiteULike Delicious Facebook Google+ Mendeley Twitter What's this? Navigate This Article Top Abstract Aetiology Pathophysiology Antenatal diagnosis Counselling and prognostic indicators Prenatal management Postnatal resuscitation and stabilization Aspects of PICU care Surgical repair Long-term outcome Footnotes References . "Congenital diaphragmatic hernia: an overview of the etiology and current management".

To date, it carries a high mortality and an active area of clinical research. Pediatr. Previous SectionNext Section Prenatal management Morphological and biochemical immaturity of the affected lung in patients with CDH suggest that surfactant deficiency may play a role in the pathophysiology of the condition. J. The authors concluded that, at the present time, we do not know if the functional derangement is attributable to iatrogenic damage occurring during the neonatal period or is a reflection of the severity of the underlying pulmonary disease. elevation) of part or all of an otherwise intact diaphragm into the chest cavity. Ten years later, the same group published a retrospective review of their experience of infants with CDH; they demonstrated an increase in survival and decreased use of extracorporeal membrane oxygenation (ECMO) associated with the use of this respiratory care strategy and delayed surgical repair. Once these initial procedures have been performed, the neonate can be transferred to the paediatric intensive care unit (PICU) where arterial and central venous access is established and routine tests, including arterial blood gases and a chest x-ray, are performed (Fig. Barbato, A. ^ Gaxiola A, Varon J, Valladolid G (April 2009).

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